The use of iron chelators in biocidal compositions: evaluation of patent, WO2014059417A1

Abstract

Anti-microbial-potentiating compositions, containing one or more anti-microbial agents and an iron chelator, are claimed in the patent application. Different combinations of anti-microbial agents with various classes of iron chelators are claimed. The use of such formulations enhances the biocidal activity of the anti-microbial agents. The compositions can be used for a number of applications, such as preservatives, personal care formulations, water-based paints, household cleaning products, and so on. These compositions have therapeutic use in the treatment of acne where they have been shown to markedly potentiate the effect of anti-microbial agents. They also have possible use in wound-healing products.

Keywords:

• anti-microbial agents
• biocidal activity
• iron chelators

Acknowledgements

We appreciate comments on the manuscript prior to submission from Patric Jansson, Zaklina Kovacevic, and Darius Lane (Molecular Pharmacology and Pathology Program, University of Sydney).

Declaration of interest

The author DR Richardson was supported by the National Health and Medical Research Council of Australia for a Senior Principal Research Fellowship and Project Grants. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.