291
Views
80
CrossRef citations to date
0
Altmetric
Review

Therapeutic potential of benzothiazoles: a patent review (2010 – 2014)

, &
Pages 335-349 | Published online: 12 Jan 2015
 

Abstract

Introduction: Benzothiazole is a versatile fused heterocyclic scaffold with extensive pharmaceutical applications. Several benzothiazole derivatives possess broad spectrum of antimicrobial, analgesic, anti-inflammatory, antidiabetic activities and so on, and the structurally simple 2-arylbenzothiazoles are potential antitumor agents. Some of the compounds containing benzothiazole ring system are in clinical usage for the treatment of various diseases/disorders.

Areas covered: In the present review, the authors summarize inventions carried out towards the development of benzothiazole-based chemotherapeutic agents. It provides an overview of the patents filed during 2010 – 2014 pertaining to the anticancer, antimicrobial, anti-inflammatory and other biological activities of benzothiazole derivatives.

Expert opinion: Several molecules containing benzothiazole skeleton are agents of choice for the treatment of various human diseases/disorders. Its versatile character of being capable of serving as ligand to various biomolecules attracted the interest of medicinal chemists for the development of therapies for respective ailments, especially, the 2-arylbenzothiazole moiety which is under development for the treatment of cancer. This signifies the increasing importance of benzothiazole nucleus in the area of drug discovery. Its structural simplicity and ease of synthesis provides scope for the development of chemical libraries that could serve in the discovery of new chemical entities progressing towards the market.

Declaration of interest

The authors have received support from CSIR, New Delhi. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Notes

This box summarizes key points contained in the article.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 99.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,757.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.