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Expert Opinion on Investigational Drugs Volume 20, 2011 - Issue 5
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Angiogenesis-related molecular targets in esophageal cancer

Liu Hong Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China +86 29 84773974; +86 29 82539041; [email protected]; [email protected]
, MD PhD,
Shujun Li Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China +86 29 84773974; +86 29 82539041; [email protected]; [email protected]
, MD PhD,
Yu Han Fourth Military Medical University, Xijing Hospital, Department of Otolaryngology, Xi'an, 710032, Shaanxi Province, China
, MD,
Jianjun Du Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China +86 29 84773974; +86 29 82539041; [email protected]; [email protected]
, MD PhD,
Hongwei Zhang Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China +86 29 84773974; +86 29 82539041; [email protected]; [email protected]
, MD,
Jipeng Li Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China +86 29 84773974; +86 29 82539041; [email protected]; [email protected]
, MD PhD,
Qingchuan Zhao Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China +86 29 84773974; +86 29 82539041; [email protected]; [email protected]
, MD,
Kaichun Wu Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China +86 29 84773974; +86 29 82539041; [email protected]; [email protected]
, MD PhD &
Daiming Fan Fourth Military Medical University, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, Xi'an, 710032, Shaanxi Province, China +86 29 84773974; +86 29 82539041; [email protected]; [email protected]
, MD PhD show all
Pages 637-644 | Published online: 28 Mar 2011
 
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Abstract

Introduction: Angiogenesis has become an appealing target in cancer therapy due to its fundamental role in cancer growth and metastasis. A number of angiogenesis-related molecules are under investigation, with some already in clinical practice with various results. The effort to present and discuss the current status of the research on the angiogenesis-related molecular targets will lead to improved clinical strategies and outcomes for patients with esophageal cancer (EC).

Areas covered : This review summarizes the recent advances in angiogenesis-related targets in EC, and also analyzes the clinical and therapeutic applications they provide. We envisage future developments towards the anti-angiogenic strategy of molecular targets and their potential applications to cancer treatment.

Expert opinion : Angiogenesis-related targets can be used as a useful therapeutic tool for EC. More investigations should be performed to promote the success of anti-angiogenic therapy in clinical trials.

Acknowledgment

L Hong, S Li and Y Han contributed equally to this work. The authors appreciate the technical help of Prof. Genlin Ji.

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