Healing of the bone with anti-fracture drugs

Abstract

Introduction: Fracture healing is a complex process that leads to the restoration of tissue integrity through bone repair and represents a unique physiological characteristic of bone. Developing a better understanding of a fracture is essential to plan best noninvasive treatment for the patient. In osteoporosis, the patient who suffers of a fragility fracture is recommended to initiate a treatment with compounds active in preventing other low-energy skeletal trauma. Pharmaceutical industries are developing controlled clinical trials aiming to evaluate the capability of osteoporosis drugs to accelerate fracture healing.

Areas covered: In preparing this review, a search was made with key words encompassing ‘osteoporosis anti-fracture drugs and bone repair/healing', ‘antiresorptives and bone repair/healing', ‘bone-forming agents and bone repair/healing', and ‘osteoporosis/anti-fracture drugs in fractures'. The results published in the area of the use of registered anti-fracture drugs to improve fracture repair and the efforts made to recommend measures for clinical outcomes in fracture healing acceleration are described in this report.

Expert opinion: At present, the use of systemic pharmacological agents active to improve fracture healing by the clinicians is controversial and clinicians and scientists must do a better job in determining the methods of assessment for fracture healing.

Keywords::

• anabolics
• anti-fracture drugs
• antiresorptives
• bone healing
• regulatory requirements

Notes

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