Pharmacotherapies and harm-reduction options for the treatment of tobacco dependence

Abstract

Introduction: Tobacco dependence, a chronic relapsing condition, requires repeated interventions and multiple attempts to quit.

Areas covered: Strategies for assisting smoking cessation include behavioural counselling and pharmacotherapy. Three drugs are currently used as first-line pharmacotherapy: nicotine replacement therapy (NRT), bupropion and varenicline. Compared to placebo, the drug effect varies from RR = 2.27 for varenicline, to 1.69 for bupropion, and 1.60 for any form of NRT. Cytisine (similar to varenicline) has a RR = 3.98 compared to placebo (two trials). Second-line pharmacotherapies include nortriptyline and clonidine. This review also offers an overview of pipeline developments.

Expert opinion: Effective medications exist, and clinicians should encourage and offer treatment to every smoker. However, most smokers try to quit by themselves, with only about 3% quitting successfully each year. Alternative interventions are needed. Harm reduction has not received much support to date. Safer alternative to tobacco smoking (smoke-free products, long-term use of cessation drugs, or electronic cigarettes) could save lives and reduce the burden of tobacco-related deaths and diseases. Despite some encouragement to develop a research agenda for e-cigarettes, particularly on the safety issues, too little attention has been brought to this area of research.

Keywords::

• bupropion
• electronic cigarette
• harm reduction
• nicotine
• nicotine replacement therapy
• smokeless tobacco
• smoking cessation
• tobacco dependence
• varenicline

Notes

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