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Sildenafil citrate for the treatment of pulmonary arterial hypertension

GALIE N, GHOFRANI HA, TORBICKI A et al.: Sildenafil citrate therapy for pulmonary arterial hypertension. N. Engl. J. Med. (2005) 353(20):2148-2157 Citation and WILKINS MR, PAUL GA, STRANGE JW et al.: Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) study. Am. J. Respir. Crit. Care Med. (2005) 171(11):1292-1297 Citation.

Pages 825-828 | Published online: 24 Mar 2006
 

Abstract

Pulmonary arterial hypertension is a life-threatening, progressive disease that is characterised by an increase of pulmonary artery pressure leading to right heart failure and death. Conventional therapy (e.g., anticoagulants, diuretics, cardiac glycoside) has until recently represented the mainstay of pulmonary arterial hypertension treatment, but newer specific therapies have become available in the meantime. Among them, are the endothelin receptor antagonists (e.g., bosentan), prostacyclin and prostanoid derivatives (e.g., epoprostenol, iloprost, beraprost, treprostinil) or phosphodiesterase-5 inhibitors (e.g. sildenafil citrate). Sildenafil citrate has recently been approved for pulmonary arterial hypertension therapy, and the two discussed clinical studies assessed its safety and efficacy.

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