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Expert Opinion on Pharmacotherapy Volume 8, 2007 - Issue 16
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Review

Treatment strategy to eradicate Helicobacter pylori infection: impact of pharmacogenomics-based acid inhibition regimen and alternative antibiotics

Mitsushige Sugimoto Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD, PhD,,
Takahisa Furuta Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD, PhD,,
Naohito Shirai Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD, PhD,
Chise Kodaira Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD,,
Masafumi Nishino Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD,
Mihoko Yamade Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD,,
Mutsuhiro Ikuma Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD, PhD,,
Hiroshi Watanabe Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD, PhD,,
Kyoichi Ohashi Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD, PhD,,
Akira Hishida Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD, PhD, &
Takashi Ishizaki Hamamatsu University School of Medicine, First Department of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan +81 53 435 2261; +81 53 434 9447; [email protected]
, MD, PhD show all
Pages 2701-2717 | Published online: 24 Oct 2007
 
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Abstract

The eradication rates of Helicobacter pylori by the triple therapy consisting of a proton pump inhibitor (PPI) and two antimicrobial agents are mainly influenced by bacterial susceptibility to antimicrobial agents and magnitude of acid inhibition during the treatment with a PPI. Acid inhibition during the treatment is affected by the dosing schemes of acid inhibitory drugs (i.e., PPI), genotypes of drug-metabolizing enzymes (i.e., CYP450 2C19), drug transporters (i.e., multi-drug resistant transporter-1) and inflammatory cytokines (i.e., IL-1β). Modification of dosing schedules of a PPI, such as frequent PPI dosing and concomitant dosing with a histamine 2-receptor antagonist, could overcome these genetics-related differences in therapeutic effectiveness. For attaining higher eradication rates, the tailored regimen based on the relevant pharmacogenomics is preferable.

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