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Expert Opinion on Biological Therapy Volume 12, 2012 - Issue 8
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Review Article

The role of biologic agents in the management of non-infectious uveitis

Jangwon HeoJohns Hopkins University School of Medicine, Wilmer Eye Institute, Johns Hopkins Hospital, Retinal Imaging Research and Reading Center, 600 North Wolfe Street, Maumenee 745, Baltimore, MD 21287, USA+1 410 502 0766; +1 410 502 1712; [email protected]
, MD,
Yasir J SepahJohns Hopkins University School of Medicine, Wilmer Eye Institute, Johns Hopkins Hospital, Retinal Imaging Research and Reading Center, 600 North Wolfe Street, Maumenee 745, Baltimore, MD 21287, USA+1 410 502 0766; +1 410 502 1712; [email protected]
, MBBS,
Jithin YohannanJohns Hopkins University School of Medicine, Wilmer Eye Institute, Johns Hopkins Hospital, Retinal Imaging Research and Reading Center, 600 North Wolfe Street, Maumenee 745, Baltimore, MD 21287, USA+1 410 502 0766; +1 410 502 1712; [email protected]
, BA,
Morgan RennerJohns Hopkins University School of Medicine, Wilmer Eye Institute, Johns Hopkins Hospital, Retinal Imaging Research and Reading Center, 600 North Wolfe Street, Maumenee 745, Baltimore, MD 21287, USA+1 410 502 0766; +1 410 502 1712; [email protected]
, MD,
Abeer AkhtarJohns Hopkins University School of Medicine, Wilmer Eye Institute, Johns Hopkins Hospital, Retinal Imaging Research and Reading Center, 600 North Wolfe Street, Maumenee 745, Baltimore, MD 21287, USA+1 410 502 0766; +1 410 502 1712; [email protected]
, BS,
Anthony GregoryJohns Hopkins University School of Medicine, Wilmer Eye Institute, Johns Hopkins Hospital, Retinal Imaging Research and Reading Center, 600 North Wolfe Street, Maumenee 745, Baltimore, MD 21287, USA+1 410 502 0766; +1 410 502 1712; [email protected]
, MD,
Mathew ShulmanJohns Hopkins University School of Medicine, Wilmer Eye Institute, Johns Hopkins Hospital, Retinal Imaging Research and Reading Center, 600 North Wolfe Street, Maumenee 745, Baltimore, MD 21287, USA+1 410 502 0766; +1 410 502 1712; [email protected]
, BA,
Diana V DoJohns Hopkins University School of Medicine, Wilmer Eye Institute, Johns Hopkins Hospital, Retinal Imaging Research and Reading Center, 600 North Wolfe Street, Maumenee 745, Baltimore, MD 21287, USA+1 410 502 0766; +1 410 502 1712; [email protected]
, MD &
Quan Dong NguyenJohns Hopkins University School of Medicine, Wilmer Eye Institute, Johns Hopkins Hospital, Retinal Imaging Research and Reading Center, 600 North Wolfe Street, Maumenee 745, Baltimore, MD 21287, USA+1 410 502 0766; +1 410 502 1712; [email protected]
, MD MSc show all
Pages 995-1008 | Published online: 11 Jul 2012
 
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Abstract

Introduction: Uveitis is an intriguing group of disorders characterized by inflammation of the uveal tract. Due to the potential grave consequences of the disease process, it is important to assess the various therapeutic options available for treating uveitis, and their outcomes.

Areas covered: This review discusses the use of conventional agents in the management of uveitis, including discussion of the molecular and clinical properties of corticosteroids, antimetabolites, calcineurin inhibitors and alkylating agents and their side effects. In addition, it also discusses the molecular and clinical properties of novel biologic agents and their side effects. Moreover, recommendations as to when biologic agents should be employed are also discussed.

Expert opinion: We recommend that in general (except in selected cases of Adamantiades-Behçet's disease) biologics should not be used as a first-line therapy for uveitis due to inconvenience, high cost, and potential immunosuppressive effects. However, many biologics are potent in inducing drug-free remission of uveitis and may be employed to manage recurrent diseases or diseases not responsive to conventional agents.

Acknowledgement

Both J Heo and YJ Sepah have contributed equally to the preparation of this manuscript and both serve as first authors.

Notes

This box summarizes key points contained in the article.

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