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Expert Opinion on Biological Therapy Volume 6, 2006 - Issue 5
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Review

Biological response modifiers as adjuncts to stem cell transplantation

Michael Y Shapira Hadassah University Hospital, Department of Bone Marrow Transplantation and Cancer Immunotherapy, PO Box 12000, Jerusalem 91120, Israel. [email protected]
,
Igor B Resnick Hadassah University Hospital, Department of Bone Marrow Transplantation and Cancer Immunotherapy, PO Box 12000, Jerusalem 91120, Israel. [email protected]
,
Panagiotis D Tsirigotis Hadassah University Hospital, Department of Bone Marrow Transplantation and Cancer Immunotherapy, PO Box 12000, Jerusalem 91120, Israel. [email protected]
&
Shimon Slavin Hadassah University Hospital, Department of Bone Marrow Transplantation and Cancer Immunotherapy, PO Box 12000, Jerusalem 91120, Israel. [email protected]
Pages 467-483 | Published online: 13 Apr 2006
 
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Abstract

Cytokines produced by immune and non-immune cells serve as potent mediators with the properties of signal cells that coordinate the immune response. They are delivered by cells either to the systemic circulation or to the local environment. They are being used at present in the field of stem cell transplantation (SCT) in order to improve transplant outcome. This paper reviews the existing data on pre-, peri- and post-SCT treatment with cytokines.

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