147
Views
28
CrossRef citations to date
0
Altmetric
Review

Gene therapy for disc degeneration

, &
Pages 185-196 | Published online: 24 Jan 2007
 

Abstract

Recent advances in our understanding of the biology of the intervertebral disc have led to increased interest in the development of novel treatments of intervertebral disc degeneration. With the ability to provide sustained delivery of a potentially therapeutic agent, gene therapy has shown much promise in regard to the treatment of disc degeneration. Many new targets for gene therapy have been identified and new vectors are being investigated for use in intervertebral disc applications. Multiple studies have demonstrated the feasibility of intradiscal gene therapy, and recent studies have shown proof of efficacy of vector-mediated gene transfer in the reproducible animal model, as well as the potential to control transgene expression, improving safety. With continued efforts, gene therapy may prove to be an extremely powerful tool in the future treatment of intervertebral disc degeneration.

Notes

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 99.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 960.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.