Possible therapeutic applications of single-chain antibodies in systemic autoimmune diseases

Abstract

B cells participate in the induction and maintenance of systemic autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, via production of pathogenic autoantibodies, contributing to the formation of immune complexes. Immune complex deposition in the kidney and joints causes inflammation and organ destruction, and chemokine production enhances T cell activation and tissue damage. The development of the disorder depends on several factors, for example, genetic susceptibility, environmental factors or immune dysregulation. Traditional therapies, which aimed at the alleviation of symptoms, are giving way to biological therapies with the potential of disrupting disease progression. This article focuses on antibody therapies, especially on the applications of single-chain antibodies, as new biological agents for the treatment of systemic autoimmune disorders.

Keywords::

• antibody therapy
• autoimmunity
• inflammation
• single-chain fragment variable

Acknowledgements

The work in the authors’ laboratory was supported by National Research and Development Foundation NKFP-1A/040/2004; GVOP 3.1.1.2004-05-0183/3.0 and the Peter Pazmany programme of the National Office for Research and Technology.

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