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Expert Opinion on Therapeutic Targets Volume 11, 2007 - Issue 8
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Review

The non-genomic crosstalk between PPAR-γ ligands and ERK1/2 in cancer cell lines

Efstathia Papageorgiou Professor and Chairman National & Kapodistrian University of Athens, Department of Experimental Physiology, Medical School, 75 Micras Asias St, Goudi-Athens 11527, Greece +30 2107462597; +30 2107462571; [email protected]
, BSc,
Nea Pitulis Professor and Chairman National & Kapodistrian University of Athens, Department of Experimental Physiology, Medical School, 75 Micras Asias St, Goudi-Athens 11527, Greece +30 2107462597; +30 2107462571; [email protected]
, BSc,
Pavlos Msaouel Professor and Chairman National & Kapodistrian University of Athens, Department of Experimental Physiology, Medical School, 75 Micras Asias St, Goudi-Athens 11527, Greece +30 2107462597; +30 2107462571; [email protected]
, MD,
Peter Lembessis Professor and Chairman National & Kapodistrian University of Athens, Department of Experimental Physiology, Medical School, 75 Micras Asias St, Goudi-Athens 11527, Greece +30 2107462597; +30 2107462571; [email protected]
, PhD &
Michael Koutsilieris Professor and Chairman National & Kapodistrian University of Athens, Department of Experimental Physiology, Medical School, 75 Micras Asias St, Goudi-Athens 11527, Greece +30 2107462597; +30 2107462571; [email protected]
, MD PhD
Pages 1071-1085 | Published online: 31 Jul 2007
 
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Abstract

Peroxisome proliferator activated receptors (PPARs) are members of the nuclear receptor superfamily acting as transcription factors. PPAR-γ, one of the three PPAR subtypes, is expressed in many malignant and non-malignant cells and tissues. PPAR-γ ligands influence cancer biology via both genomic as well as non-genomic events. The non-genomic action of PPAR-γ ligands, including the activation of MAPK signaling pathways, is under intense investigation. In the presence of PPAR-γ ligands, a rapid phosphorylation of ERK1/2 is observed in many cancer cell lines. Activated ERK1/2 elicits rapid, non-genomic cellular effects and can directly repress PPAR-γ transcriptional activity by phosphorylation. This paper reviews the interrelation of PPAR-γ ligands and activated ERK1/2, in relation to their antineoplastic actions in cancer cell lines, which may offer the potential for improved anticancer therapies.

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