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Expert Opinion on Therapeutic Targets Volume 18, 2014 - Issue 9
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Original Research

Correlation of platelet activating factor and age-related macular degeneration

Eirini NitodaNational and Kapodistrian University of Athens, 1st Department of Ophthalmology, Medical School, Athens, Greece+306944887319; +302104122319; [email protected]
, MD MSc,
Michael KoutsilierisNational and Kapodistrian University of Athens, Department of Experimental Physiology, Medical School, Athens, Greece
, MD PhD,
Dimitrios BrouzasNational and Kapodistrian University of Athens, 1st Department of Ophthalmology, Medical School, Athens, Greece+306944887319; +302104122319; [email protected]
, MD PhD,
Chryssanthi KoutsandreaNational and Kapodistrian University of Athens, 1st Department of Ophthalmology, Medical School, Athens, Greece+306944887319; +302104122319; [email protected]
, MD PhD,
Anastasios PhilippouNational and Kapodistrian University of Athens, Department of Experimental Physiology, Medical School, Athens, Greece
, MSc,
Dimitrios LadasNational and Kapodistrian University of Athens, 1st Department of Ophthalmology, Medical School, Athens, Greece+306944887319; +302104122319; [email protected]
, MD PhD &
Marilita M MoschosNational and Kapodistrian University of Athens, 1st Department of Ophthalmology, Medical School, Athens, Greece+306944887319; +302104122319; [email protected]
, MD PhD show all
Pages 987-997 | Published online: 31 Jul 2014
 
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Abstract

Objective: To investigate the role of Platelet Activating Factor (PAF) in the pathogenesis and development of Age-Related Macular Degeneration (ARMD).

Research design and methods: Fifty six patients with ARMD (24 patients with dry ARMD and 32 patients with wet ARMD) and 25 age-matched control participants underwent ophthalmological examination, including visual acuity measurement and evaluation of the retina. The participants were classified into three groups according to their retinal status, based on indirect fundoscopy, Optical Coherence Tomography and fluorescein angiography findings. In order to evaluate the concentrations of PAF in serum, blood samples were collected from all participants and were analyzed with ELISA technique.

Results: The concentrations of PAF differed significantly according to macular lesions and were found to be lower in patients with ARMD than control participants.

Conclusions: PAF levels are decreased along with the severity of ARMD. Understanding the role of PAF in pathogenesis of ARMD could be the impetus for the development of new therapies field of treatment of ARMD or even other retinal diseases.

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