GABA and glutamate systems as therapeutic targets in depression and mood disorders

Steven F Kendell Yale University School of Medicine, Department of Psychiatry, 333 Cedar Street, New Haven, CT 06510, USA. [email protected]

John H Krystal Yale University School of Medicine, Department of Psychiatry, 333 Cedar Street, New Haven, CT 06510, USA. [email protected]

Gerrard Sanacora Connecticut Mental Health Center, Clinical Neuroscience Research Unit, 34 Park Street, New Haven, CT 06519, USA

Pages 153-168 | Published online: 22 Apr 2005

Cite this article
https://doi.org/10.1517/14728222.9.1.153

Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

References
Citations
Metrics
Reprints & Permissions
Read this article /doi/epdf/10.1517/14728222.9.1.153?needAccess=true

Abstract

Advances made in diverse areas of neuroscience suggest that neurotransmitter systems, additional to the monoaminergic, contribute to the pathophysiology of mood disorders. This ever accruing body of preclinical and clinical research is providing increased recognition of the contribution made by amino acid neurotransmitters to the neurobiology of mood disorders. This review examines evidence supporting the role of GABA and glutamate in these processes and explores the potential to target these systems in the development of novel compounds; the viability of these agents for treatment-related co-morbidities will also be considered.

Keywords

depression
GABA
glutamate
mood disorder
NMDA

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.