Abstract
Rapid developments at the intersection of nanotechnology and controlled drug delivery have triggered exceptional growth in treating various bone diseases. As a result, over the past decade, nanotechnology has contributed tremendously to controlling drug delivery for treating various bone diseases, and in many cases, has led to increased bone regeneration. In this review paper, the recent experimental progress towards using nanotechnology to treat bone-specific diseases is reviewed. Novel applications of different types of nanomaterials (from nanoparticles to 3D nanostructured scaffolds) for treating bone diseases are summarized. In addition, fundamental principles for utilizing nanomaterials to create better drug delivery systems, especially for treating bone diseases and regenerating bone, are emphasized.
Notes
Win KY, Feng S. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 2005;26:2713-22 Cai Y, Pan H, Xu X, et al. Ultrasonic controlled morphology transformation of hollow calcium phosphate nanospheres: a smart and biocompatible drug release system. Chem Mater 2007;19:3081-3 Pareta RA, Taylor E, Webster TJ. Increased osteoblast density in the presence of novel calcium phosphate coated magnetic nanoparticles. Nanotechnology 2008;19:265101 Matsuo T, Sugita T, Kubo T, et al. Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. J Biomed Mater Res A 2003;66A:747-54 Sirivisoot S, Webster TJ. Multiwalled carbon nanotubes enhance electrochemical properties of titanium to determine in situ bone formation. Nanotechnology 2008;19:295101 Li C, Vepari C, Jin HJ, et al. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 2006;27(16):3115-24 Hosseinkhani H, Hosseinkhani M, Khademhosseini A, et al. Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold. J Control Release 2007;117:380-6 Jabbarzadeh E, Nair LS, Khan YM, et al. Apatite nano-crystalline surface modification of poly (lactide-co-glycolide) sintered microsphere scaffolds for bone tissue engineering: implications for protein adsorption. J Biomater Sci Polymer Edn 2007;18:1141-52 Wei G, Jin Q, Giannobile WV, et al. The enhancement of osteogenesis by nanofibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials 2007;28:2087-96