Advanced search
Publication Cover
Expert Opinion on Drug Delivery Volume 8, 2011 - Issue 4
Submit an article Journal homepage
474
Views
49
CrossRef citations to date
0
Altmetric
Reviews

Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis

Nupura S Bhise Johns Hopkins University School of Medicine, Department of Biomedical Engineering, 400 N Broadway, Smith 5017, Baltimore, MD 21231, USA +1 410 416 9113; +1 443 287 6298; [email protected]
,
Ron B Shmueli Johns Hopkins University School of Medicine, Department of Biomedical Engineering, 400 N Broadway, Smith 5017, Baltimore, MD 21231, USA +1 410 416 9113; +1 443 287 6298; [email protected]
,
Joel C Sunshine Johns Hopkins University School of Medicine, Department of Biomedical Engineering, 400 N Broadway, Smith 5017, Baltimore, MD 21231, USA +1 410 416 9113; +1 443 287 6298; [email protected]
,
Stephany Y Tzeng Johns Hopkins University School of Medicine, Department of Biomedical Engineering, 400 N Broadway, Smith 5017, Baltimore, MD 21231, USA +1 410 416 9113; +1 443 287 6298; [email protected]
&
Jordan J Green Johns Hopkins University School of Medicine, Department of Biomedical Engineering, 400 N Broadway, Smith 5017, Baltimore, MD 21231, USA +1 410 416 9113; +1 443 287 6298; [email protected]
Pages 485-504 | Published online: 22 Feb 2011
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Introduction: Angiogenesis is essential to human biology and of great clinical significance. Excessive or reduced angiogenesis can result in, or exacerbate, several disease states, including tumor formation, exudative age-related macular degeneration (AMD) and ischemia. Innovative drug delivery systems can increase the effectiveness of therapies used to treat angiogenesis-related diseases.

Areas covered: This paper reviews the basic biology of angiogenesis, including current knowledge about its disruption in diseases, with the focus on cancer and AMD. Anti- and proangiogenic drugs available for clinical use or in development are also discussed, as well as experimental drug delivery systems that can potentially improve these therapies to enhance or reduce angiogenesis in a more controlled manner.

Expert opinion: Laboratory and clinical results have shown pro- or antiangiogenic drug delivery strategies to be effective in drastically slowing disease progression. Further research in this area will increase the efficacy, specificity and duration of these therapies. Future directions with composite drug delivery systems may make possible targeting of multiple factors for synergistic effects.

Notes

This box summarizes key points contained in the article.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 99.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 876.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.