Chitosan-based gastroretentive floating drug delivery technology: an updated review

Abstract

Introduction: Gastroretentive floating drug delivery systems have emerged as efficient approaches for enhancing the bioavailability and controlled delivery of various therapeutic agents. Significant advancements exploiting chitosan have been made worldwide, in order to investigate these systems according to patient requirements, both in terms of therapeutic efficacy as well as patient compliance. Such systems precisely control the release rate of the target drug to a specific site, which facilitates an enormous impact on health care.

Areas covered: Different novel strategies have been undertaken for the development of various gastric floating dosage forms utilizing chitosan as a promising excipient. The present paper is an earnest attempt to provide new insights on various physicochemical and biological characteristics of chitosan, along with its potential applications in a wide array of biomedical approaches. Numerous and significant research findings in the vistas of chitosan-based gastroretentive floating drug delivery technology are also discussed.

Expert opinion: Chitosan has been considered as a unique and efficacious agent possessing a myriad spectrum of desired characteristics. It is emphasized that recent scientific advancements in the use of this excipient as a carrier will yield new generation gastroretentive drug delivery systems, with better pharmacotherapeutic interventions. Further studies are required to unveil the hidden beneficial properties of chitosan and its derivatives, to obtain newer delivery systems which may hold tremendous prospects in the near future.

Keywords::

• bioavailability
• chitosan
• floating drug delivery systems
• gastroretentive technology

Acknowledgements

Lt. Gen. DDS Sandhu, Vice Chancellor, Kurukshetra University, Kurukshetra-136119, India, is duly acknowledged for providing necessary facilities. The authors also thank PC Sharma, Assistant Professor, Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India, for his valuable suggestions.