Novel materials which possess the ability to target liver cells

Abstract

Introduction: Hepatic-targeted drug delivery systems are designed to treat diseases of the liver. However, since there are several different types of liver diseases that are caused by different cells, it is important to select the proper materials to target these different cells.

Areas covered: This review addresses novel materials that possess the ability to target liver cells via receptor–ligand processes and offers an insight into the aspects of formulation design. It also discusses several approaches used to enhance the targeting efficiency of drug delivery systems to receptors in the liver cells. In addition, the delivery efficiency and therapeutic efficacy of these materials in the treatment of acute or chronic liver diseases is highlighted.

Expert opinion: Further research into the use of clinical materials and the design of smart materials for multi-drug delivery to different organelles is important for future studies on these new materials. It is hoped that these targeted therapeutics will benefit patients with liver disorders in the near future.

Keywords::

• hepatic non-parenchymal cell
• hepatic parenchymal cell
• liver targeting
• novel material

Acknowledgement

ZP Chen and L Xiao contributed equally to the project and are considered co-first authors.