Albumin–drug conjugates in the treatment of hepatic disorders

Abstract

Introduction: This review deals with the use of serum albumin (SA) as a carrier for the selective delivery of drugs to liver cells.

Areas covered: The synthesis and properties of the SA conjugates prepared to enhance the performance of the drugs used in the treatment of viral hepatitis, hepatocellular carcinoma (HCC), liver micrometastases and hepatic fibrosis are reported.

Expert opinion: Studies in humans and laboratory animals demonstrated the capacity of SA conjugates to accomplish a liver targeting of the drugs, but at the same time underscored their limits and drawbacks, which can explain why to date these complexes did not reach a practical application. The major drawback is the need of administration by intravenous route, which prevents long-term daily treatments as required by some liver pathologies, such as chronic virus hepatitis and fibrosis. At present, only a conjugate carrying doxorubicin and addressed to the treatment of HCC showed in laboratory animals a solid potentiality to improve the value of the coupled drug. In the future, conjugation to SA could remain a successful strategy to permit the administration of drugs with rapid resolutive effects inside liver cells without causing severe extrahepatic adverse reactions.

Keywords::

• asialoglycoprotein receptor
• hepatocellular carcinoma
• liver fibrosis
• liver micrometastases
• liver targeting of drugs
• mannose-6-phosphate receptor
• virus hepatitis

Acknowledgments

The authors are grateful to Prof. Massimo Derenzini from the Department of Experimental, Diagnostic and Specialty Medicine (University of Bologna) for the pictures showed in Figure 1.

Notes

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