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Expert Opinion on Drug Delivery Volume 13, 2016 - Issue 1
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Original Research

Photosensitizer-assembled PEGylated graphene-copper sulfide nanohybrids as a synergistic near-infrared phototherapeutic agent

Chunhui WuDepartment of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu610054, P.R. China;Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu610054, P.R. ChinaView further author information
,
Anni ZhuDepartment of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu610054, P.R. ChinaView further author information
,
Dan LiDepartment of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu610054, P.R. ChinaView further author information
,
Lianhui WangDepartment of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu610054, P.R. ChinaView further author information
,
Hong YangDepartment of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu610054, P.R. ChinaView further author information
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Hongjuan ZengDepartment of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu610054, P.R. China;Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu610054, P.R. ChinaView further author information
&
Yiyao LiuDepartment of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu610054, P.R. China;Center for Information in BioMedicine, University of Electronic Science and Technology of China, Chengdu610054, P.R. ChinaCorrespondence[email protected]
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Pages 155-165 | Published online: 30 Nov 2015
 
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Abstract

Objectives: Stimulative nanostructures play a crucial role in developing the smart nanomedicine for high therapeutic efficacy with minimum adverse effects. Herein, a near-infrared (NIR) light-responsive nanohybrids p-nanographene oxide (GO)-copper sulfide (CuS)/indocyanine green (ICG) comprised of GO, CuS nanoparticles and photosensitizer ICG was fabricated to couple the photothermal property of CuS and photodynamic effect of ICG in one system in order to achieve the synergistic phototherapy.

Methods: pGO-CuS/ICG was constructed by self-assembling ICG on pGO-CuS nanostructure. Its physicochemical, photothermal and photodynamic properties were studied by spectroscopic methods. The in vitro cellular uptake, cytotoxicity, the single/combined photothermal therapeutic (PTT) and photodynamic therapeutic (PDT) effects were investigated with biological techniques.

Results: pGO-CuS/ICG exhibited high efficacy of photothermal conversation and singlet oxygen generation under NIR laser excitation. It entered into the target cancer cells probably via passive transmembrane pathway and exerted obvious PTT and PDT effect against the tumor cells upon irradiation with the respective 940 and 808 nm lasers. In particular, the tremendous synergistic efficacy of PDT and PTT had been demonstrated by tuning the NIR laser combined irradiation.

Conclusions: This study promises the future applications of pGO-CuS/ICG as a NIR light activable theranostic nanodrug for deep-seated cancer noninvasive phototherapy.

Supplemental data for this article can be accessed here.

Additional information

Funding

This work was funded in great part by National Science Foundation Grant No. 0732233, “Learning Progressions for Scientific Inquiry: A Model Implementation in the Context of Energy.”

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