Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs

Abstract

The supersaturatable self-emulsifying drug delivery system (S-SEDDS) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of a surfactant and a water-soluble cellulosic polymer (or other polymers) to prevent precipitation of the drug by generating and maintaining a supersaturated state in vivo. The S-SEDDS formulations can result in enhanced oral absorption as compared with the related self-emulsifying drug delivery systems (SEDDS) formulation and the reduced surfactant levels may minimise gastrointestinal surfactant side effects.

Keywords::

• bioavailability
• lipid-based formulations
• microemulsion
• oral delivery
• poorly soluble drugs
• self-emulsifying drug delivery systems
• supersaturation
• surfactant