Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders

Abstract

Background: Fexofenadine is one of several second-generation H₁-antihistamines approved for the treatment of various allergic disorders; however, it shows numerous unique properties that make it an optimal choice for many patients. Objective: To review the pharmacology, efficacy and safety of fexofenadine and the attributes differentiating it from other H₁-antihistamines. Methods: We performed a literature search in PubMed/MEDLINE (1966 – March 2009) using the keywords fexofenadine, antihistamine, allergic rhinitis and chronic urticaria. We also reviewed data provided by the manufacturer in addition to reports from various governmental agencies. Results/conclusions: Fexofenadine is devoid of sedative and anticholinergic effects and may offer equivalent or greater efficacy in treating allergic disorders compared with other currently available second-generation H₁-antihistamines. In addition, fexofenadine may offer cost savings over other selected H₁-antihistamines owing to its recent availability in generic form in the US.

Keywords::

• allergic rhinitis
• antihistamine
• fexofenadine
• H₁-antihistamine
• nonsedating