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Expert Opinion on Drug Metabolism & Toxicology Volume 5, 2009 - Issue 9
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Drug Evaluations

Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects

Shilpi Pradhan Cornea Fellow and Clinical Instructor, University of Pittsburgh Medical Center, Eye and Ear Institute, 203 Lothrop Street, Pittsburgh, PA 15213, USA
, MD,
Kumar Abhishek Internal Medicine Hospitalist, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
, MD &
Francis Mah Assistant Professor, Co-Medical Director, University of Pittsburgh Medical Center, Eye and Ear Institute, Ophthalmology, Charles T. Campbell Ophthalmic Microbiology Laboratory, 203 Lothrop Street, Pittsburgh, PA 15213, USA +1 412 647 2214; +1 412 647 5119; [email protected]
, MD
Pages 1135-1140 | Published online: 27 Jul 2009
 
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Abstract

Background: Epinastine is a topical ophthalmic antihistamine and a mast cell stabilizer indicated for treatment of symptoms associated with allergic conjunctivitis. Objective: The objective of this review is to provide a comprehensive overview of the pharmacology, clinical efficacy, tolerability and safety of epinastine 0.05% ophthalmic solution. Methods: Medline literature review from 1950 to 2008. Conclusions: Epinastine 0.05% ophthalmic solution was found to be a safe and effective medication for the relief of symptoms of allergic conjunctivitis. Epinastine demonstrates very low CNS and cardiac toxicity.

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