Current and future directions of pharmacokinetic and pharmacokinetic–pharmacodynamic modelling and simulation: Population Approach Group in Europe 19th annual meeting

Abstract

The Population Approach Group in Europe meeting is the annual meeting of a group of scientists interested in quantitative pharmacology approaches. This meeting provides insights on new modelling approaches and applications thereof in different therapeutic areas and in different phases of drug development, in which modelling and simulation is set ‘at work’. These meeting highlights mainly focus on the contributions pertinent to this journal, such as physiology-based pharmacokinetic modelling, modelling of pharmacokinetic–pharmacodynamic relationships (including binary/categorical end points) in non-clinical studies and also include presentations of junior scientists in the annual Lewis Sheiner Student Session.

Keywords::

• modelling
• NONMEM
• pharmacokinetics
• pharmacokinetic–pharmacodynamic
• pharmacometrics
• population approaches
• SYMCYP™
• WinBUGS

Acknowledgements

C Kloft and I Poggesi would like to thank warmly the authors of the PAGE contributions for their revisions and A Vermeulen for the useful comments to these meeting highlights.