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Expert Opinion on Drug Metabolism & Toxicology Volume 10, 2014 - Issue 8
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Drug Evaluations

Evaluation of acotiamide for the treatment of functional dyspepsia

Yan SunTexas Tech University and Health Science Center, Internal Medicine Department, 4800 Albert Avenue, El Paso, TX 79905, USA+1 915 5456 627; +1 915 545 9765; [email protected]
, MD PhD,
Gengqing SongTexas Tech University and Health Science Center, Internal Medicine Department, 4800 Albert Avenue, El Paso, TX 79905, USA+1 915 5456 627; +1 915 545 9765; [email protected]
, MD PhD &
Richard W McCallumTexas Tech University and Health Science Center, Internal Medicine Department, 4800 Albert Avenue, El Paso, TX 79905, USA+1 915 5456 627; +1 915 545 9765; [email protected]
, MD
Pages 1161-1168 | Published online: 31 May 2014
 
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Abstract

Introduction: The treatment for functional dyspepsia (FD) (indigestion) remains unsatisfactory. Acotiamide is a new prokinetic that has been recently approved and used in Japan for the treatment of FD.

Areas covered: This review introduces the pharmacodynamics, pharmacokinetics and efficacy data from current clinical trials from literature sourced using the PubMed search tools. Future principles for developing drugs and designing clinical trials to test them for treating FD are also discussed.

Expert opinion: Acotiamide can contribute to the treatment of the specific subset of symptoms defined as postprandial FD by reducing the impaired fundic relaxation and accommodation after eating. The agent has the added benefit of a very good safety profile.

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