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Expert Opinion on Drug Metabolism & Toxicology Volume 4, 2008 - Issue 3
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Review

Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development of in vitro high-speed screening systems

Ai Tamura Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan +81 45 924 5800; +81 45 924 5838; [email protected]
,
Ran An Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan +81 45 924 5800; +81 45 924 5838; [email protected]
,
Yuichiro Hagiya Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan +81 45 924 5800; +81 45 924 5838; [email protected]
,
Kazuyuki Hoshijima Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan +81 45 924 5800; +81 45 924 5838; [email protected]
, PhD,
Takashi Yoshida Yokogawa Electric Corporation, Life Science Business Headquarters, Drug Discovery Solution Department, Kanazawa, Japan
, PhD,
Kenta Mikuriya Yokogawa Electric Corporation, Life Science Business Headquarters, Drug Discovery Solution Department, Kanazawa, Japan
, PhD &
Toshihisa Ishikawa Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biomolecular Engineering, 4259-B-60 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan +81 45 924 5800; +81 45 924 5838; [email protected]
, PhD show all
Pages 255-272 | Published online: 26 Mar 2008
 
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Abstract

Background: Photosensitivity depends on both genetic and environmental factors. Pheophorbide a, present in various plant-derived foods and food supplements, can be absorbed by the small intestine. Accumulation of pheophorbide a and porphyrins in the systemic blood circulation can result in phototoxic lesions on light-exposed skin. Objective: As the human ATP-binding cassette (ABC) transporter ABCG2 has been suggested to be critically involved in porphyrin-mediated photosensitivity, we aimed to develop in vitro screening systems for drug-induced phototoxicity. Conclusion: Functional impairment owing to inhibition of ABCG2 by drugs or its genetic polymorphisms can lead to the disruption of porphyrin homeostasis. This review article provides an overview on drug-induced photosensitivity, as well as our hypothesis on a potential role of ABCG2 in phototoxicity.

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