Potential of zebrafish for anticancer drug screening

Abstract

Background: The zebrafish is a powerful vertebrate model organism for large scale genetic and chemical screens. Objective: With the rapid development of cancer modeling in zebrafish, great opportunities exist for chemical screens to find anticancer agents. Methods: Using embryos, pathway screens can be designed based on our knowledge of cancer biology. Anticancer chemical screens using tumor bearing adult zebrafish facilitate preclinical testing. Conclusion: Current developments in improving cancer models and automated imaging technology have the potential of finding novel compounds that disrupt tumor biology.

Keywords::

• cancer model
• chemical screen
• zebrafish

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