Potential of phage-displayed peptide library technology to identify functional targeting peptides

Abstract

Combinatorial peptide library technology is a valuable resource for drug discovery and development. Several peptide drugs developed through phage-displayed peptide library technology are presently in clinical trials and the authors envision that phage-displayed peptide library technology will assist in the discovery and development of many more. This review attempts to compile and summarize recent literature on targeting peptides developed through peptide library technology, with special emphasis on novel peptides with targeting capacity evaluated in vivo.

Keywords::

• library
• peptide
• phage display
• targeting

Acknowledgements

The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.This Research was supported (in part) by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.