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Expert Opinion on Drug Discovery Volume 8, 2013 - Issue 3
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Animal models of skin disease for drug discovery

Pinar AvciMassachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA+1 617 726 6182; +1 617 726 8566; [email protected];Harvard Medical School, Department of Dermatology, Boston, MA 02115, USA
, MD,
Magesh SadasivamMassachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA+1 617 726 6182; +1 617 726 8566; [email protected];Amity University Uttar Pradesh, Amity Institute of Nanotechnology, Noida-201303, India
, MTech,
Asheesh GuptaMassachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA+1 617 726 6182; +1 617 726 8566; [email protected];Harvard Medical School, Department of Dermatology, Boston, MA 02115, USA;Defense Institute of Physiology and Allied Sciences, Timarpur, Delhi-110 054, India
, PhD,
Wanessa CMA De MeloMassachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA+1 617 726 6182; +1 617 726 8566; [email protected];University of Sao Paulo, Sao Carlos-SP, Brazil
, MS,
Ying-Ying HuangMassachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA+1 617 726 6182; +1 617 726 8566; [email protected];Harvard Medical School, Department of Dermatology, Boston, MA 02115, USA;Aesthetic and Plastic Center of Guangxi Medical University, Nanning, China
, MD,
Rui YinMassachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA+1 617 726 6182; +1 617 726 8566; [email protected];Harvard Medical School, Department of Dermatology, Boston, MA 02115, USA;Third Military Medical University, Southwest Hospital, Department of Dermatology, District Shapingba, Chongqing 400038, People's Republic of China
, MD PhD,
Rakkiyappan ChandranMassachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA+1 617 726 6182; +1 617 726 8566; [email protected];Amity University Uttar Pradesh, Amity Institute of Nanotechnology, Noida-201303, India
, MTech,
Raj KumarMassachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA+1 617 726 6182; +1 617 726 8566; [email protected];Harvard Medical School, Department of Dermatology, Boston, MA 02115, USA
, PhD,
Ayodeji OtufoworaMassachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA+1 617 726 6182; +1 617 726 8566; [email protected]
, MD,
Theodore NyameMassachusetts General Hospital, Harvard Medical School, Division of Plastic and Reconstructive Surgery, Boston, MA 02115, USA
, MD &
Michael R HamblinMassachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, Boston, MA 02114, USA+1 617 726 6182; +1 617 726 8566; [email protected];Harvard Medical School, Department of Dermatology, Boston, MA 02115, USA;Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA
, PhD show all
Pages 331-355 | Published online: 08 Jan 2013
 
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Abstract

Introduction: Discovery of novel drugs, treatments, and testing of consumer products in the field of dermatology is a multi-billion dollar business. Due to the distressing nature of many dermatological diseases, and the enormous consumer demand for products to reverse the effects of skin photodamage, aging, and hair loss, this is a very active field.

Areas covered: In this paper, we will cover the use of animal models that have been reported to recapitulate to a greater or lesser extent the features of human dermatological disease. There has been a remarkable increase in the number and variety of transgenic mouse models in recent years, and the basic strategy for constructing them is outlined.

Expert opinion: Inflammatory and autoimmune skin diseases are all represented by a range of mouse models both transgenic and normal. Skin cancer is mainly studied in mice and fish. Wound healing is studied in a wider range of animal species, and skin infections such as acne and leprosy also have been studied in animal models. Moving to the more consumer-oriented area of dermatology, there are models for studying the harmful effect of sunlight on the skin, and testing of sunscreens, and several different animal models of hair loss or alopecia.

Acknowledgements

We are grateful to VJB de Arce for editorial assistance. Research in the Hamblin laboratory is supported by the US NIH (R01AI050875). A Gupta was supported by Department of Science and Technology, Government of India (BOYCAST Fellowship 2010-11). Rui Yin was supported by the National Natural Science Foundation of China (Grant No. 81172495).

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