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Expert Review of Anticancer Therapy Volume 1, 2001 - Issue 1
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Review

Mismatch repair defects as a cause of resistance to cytotoxic drugs

Julie AE Irving Paediatric Oncology Research Unit, Cancer Research Unit, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. [email protected]
&
Andrew G Hall Paediatric Oncology Research Unit, Cancer Research Unit, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. [email protected]
Pages 149-158 | Published online: 10 Jan 2014
 
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Abstract

In this short review, we aim to bring together the most recent evidence implicating mismatch repair pathway defects as a cause of drug resistance to a spectrum of chemotherapeutic agents in a variety of cancers. Experimental and clinical studies are discussed and possible strategies that may be employed to overcome the multidrug resistant phenotype afforded by such defects.

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