Prognostic biomarkers in resected colorectal cancer: implications for adjuvant chemotherapy

Abstract

Knowledge of the prognostic role of biomarkers in colorectal cancer is limited and the routine determination for clinical practice is not warrented. However, for some of these markers, data are promising enough for further evaluation. This review addresses a comprehensive analysis of prognostic biomarkers in colorectal cancer. Data from published studies were collected and analyzed. A sufficient level of evidence suggests that DNA indexes, angiogenesis indicators and some genetic/biochemical markers identify prognostic differences in patients with early-stage colorectal cancer. High-risk patients could be the target for future adjuvant chemotherapy trials and one or more of these markers may identify prognostic subgroups with the same TNM stage category.

• adjuvant chemotherapy
• colorectal cancer
• DNA indexes
• prognostic biomarkers
• proliferative indexes
• thymidylate synthase
• tumor-node-metastasis