Therapy options in cutaneous T-cell lymphoma

Abstract

The treatment of cutaneous T-cell lymphoma (CTCL) is continually evolving, as new and emerging drugs are added to the growing arsenal of CTCL therapy. The availability of newly approved investigational therapies, such as bexarotene, denileukin diftitox (DAB₃₈₉-IL2), monoclonal antibodies and novel chemotherapeutic agents, adds complexity to decisions on the management and treatment of CTCL patients. In formulating a treatment plan, therapeutic options are best approached through consideration of overall clinical staging (stage IA–IVB) and skin staging (T1–T4), which affect prognosis and the characteristics of each individual patient’s disease. This article will present and discuss the optimal therapeutic agents for all clinical stages of CTCL patients, based on currently available and investigational agents.

• bexarotene
• chemotherapy
• cutaneous T-cell lymphoma
• denileukin diftitox
• electron beam therapy
• interferon
• monoclonal antibodies
• mycosis fungoides
• photopheresis
• phototherapy
• retinoids
• Sezary syndrome