NMR-based metabolomics of prostate cancer: a protagonist in clinical diagnostics

ABSTRACT

Advances in the application of NMR spectroscopy-based metabolomic profiling of prostate cancer comprises a potential tactic for understanding the impaired biochemical pathways arising due to a disease evolvement and progression. This technique involves qualitative and quantitative estimation of plethora of small molecular weight metabolites of body fluids or tissues using state-of-the-art chemometric methods delivering an important platform for translational research from basic to clinical, to reveal the pathophysiological snapshot in a single step. This review summarizes the present arrays and recent advancements in NMR-based metabolomics and a glimpse of currently used medical imaging tactics, with their role in clinical diagnosis of prostate cancer.

KEYWORDS:

• Metabolomics
• prostate cancer
• NMR spectroscopy
• clinical intervention
• PET
• MRSI

Acknowledgements

Financial support was provided by Department of Biotechnology, New Delhi, India (BT/PR6547/GBD/27/450/2012) and Council of Scientific and Industrial Research (CSIR), New Delhi, India.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.