Application of genomics and proteomics in Type 1 diabetes pathogenesis research

Abstract

Type 1 diabetes is a polygenic, multifactorial autoimmune disease characterized by selective and irreversible destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans. An exogenous supply of insulin is required to sustain life after the onset of Type 1 diabetes. Despite decades of intensive research into its pathogenesis, no single gene or protein has been found to be responsible for Type 1 diabetes. This review will describe the use of large-scale genomics and proteomics in studying the pathogenesis of Type 1 diabetes, and will discuss future directions of research in the field.

• 2D gel electrophoresis
• genome scan
• genomics
• insulin-dependent diabetes mellitus
• pathogenesis
• protein expression profile
• proteome analysis
• proteomics
• transcriptomics
• Type 1 diabetes