DualChip^® microarray as a new tool in cancer research

Abstract

Over the last 5 years, the emergence of gene expression profiling using high-density DNA microarrays led to a better understanding of tumor development and identified new prognostic markers. However, high-density microarrays failed to leap from the researcher’s bench to the clinical practice due to their cost, data management and lack of standardization. DualChip^® low-density DNA microarrays were developed as a new flexible tool that is able to reliably quantify the expression of a limited number of genes of clinical relevance. This review will illustrate how DualChip technology can be applied to tumor diagnosis and tumor-acquired drug resistance.

Keywords::

• ATP-binding cassette transporter gene
• breast cancer
• DualChip^® microarray
• leukemia