Metabolomic approaches to phenotype characterization and applications to complex diseases

Abstract

Metabolites are the key regulators of systems homeostasis. As such, concentration changes of specific groups of metabolites may reflect systemic responses to environmental, therapeutic or genetic interventions. Thus, the study of metabolites is a powerful tool for the characterization of complex phenotypes as well as for the development of biomarkers for specific physiological responses. Therefore, metabolomics is a valuable platform for studies of complex diseases and the development of new therapies, both in nonclinical disease model characterization and clinical settings.

Keywords::

• biomarker
• critical path research
• metabolomics
• pharmacology
• quantitative disease model
• systems biology
• toxicology
• translational path research