Improved molecular diagnostic tools for human hookworms

Abstract

Blood-feeding hookworms are parasitic roundworms (i.e., nematodes) of major socioeconomic importance, affecting millions of people worldwide. Despite their impact on human health, little attention has been paid to improving practical methods of diagnosis. The genetic characterization of hookworms and specific diagnosis of their infections are central to elucidating the ecology and epidemiology of these parasites as well as the control of the disease they cause. Traditional coprodiagnostic methods have major limitations. This article summarizes progress in the development of molecular-analytical and -diagnostic tools, and discusses the need to establish practical ‘laboratory’ and ‘field’ assays for use in integrated hookworm prevention and control programs.

Keywords::

• human hookworm
• molecular diagnosis
• roundworm

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this special report manuscript.