Prognostic value of copeptin in patients with acute stroke

Abstract

Context: There is a need to improve stroke care through the prompt identification of stroke patients at increased risk of an adverse outcome. Objective: To evaluate the prognostic value of copeptin in patients with stroke. Methods: We systematically searched PubMed and Embase for relevant studies. Poor outcome and mortality were analyzed. Results: Twelve studies, containing 2682 patients, were included. Pooled analysis showed that copeptin is an independent prognostic marker of poor outcome after acute stroke and there is a borderline effect of copeptin in predicting mortality after acute stroke. Conclusions: Copeptin is an independent predictor of poor outcome and mortality for patients with acute stroke.

Keywords:

• acute stroke
• copeptin
• prognosis
• systematic review

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Key issues

• Copeptin is an independent prognostic marker of poor outcome after acute stroke.

• In patients with acute ischemic stroke or intracerebral hemorrhage, copeptin is an independent prognostic marker of poor outcome.

• There was generally a borderline effect of copeptin in predicting mortality after acute stroke.

• In patients with ischemic stroke, copeptin was an independent predictor of mortality.

• In patients with intracerebral hemorrhage, there was a borderline effect of copeptin in predicting mortality after acute stroke.

Notes