Diagnostic and molecular pathology of meningiomas

Abstract

This article will review the neuropathology of meningiomas. From the neurosurgeon’s point of view, accurate neuropathological diagnosis will play an increasingly important role in clinical practice. Predicting an individual patient’s prognosis will become ever more important with the advent of various new radiotherapeutic/radiosurgical modalities. Defining the optimal treatment for nonbenign meningiomas requires a robust and reproducible diagnosis. This review will therefore not only describe classical radiological and histopathological diagnosis, but will also focus on the emerging field of molecular neuropathology. Implementing these advances in our daily clinical routine holds the promise of improving diagnostic accuracy.

Keywords::

• grading
• LOH 22q
• meningiomas
• NF2
• pathology
• radiation
• surgery
• WHO