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Expert Review of Neurotherapeutics Volume 6, 2006 - Issue 6
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Review

Biomarkers in Parkinson’s disease

E Ray Dorsey Instructor in neurology and fellow in movement disorders and experimental therapeutics, University of Rochester Medical Center, 1351 Mt. Hope Avenue, Suite 223, Rochester, NY 14620, USA. [email protected]
,
Robert G Holloway Vice-chair and associate professor of neurology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 673, Rochester, NY 14620, USA. [email protected]
&
Bernard M Ravina Associate professor of neurology and Director of Movement and Inherited Neurological Unit, University of Rochester Medical Center, 1351 Mt. Hope Avenue, Suite 223, Rochester, NY 14620, USA. [email protected]
Pages 823-831 | Published online: 10 Jan 2014
 
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Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder that is largely diagnosed and managed clinically. Biomarkers, as indicators of underlying biological processes, offer the potential to identify individuals at risk for PD, screen new therapies, assist in the diagnosis and help optimize management of PD. However, to date, biomarkers, despite their considerable promise, have had limited utility in clinical trials and practice.

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