Alternative administration routes and delivery technologies for polio vaccines

ABSTRACT

Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccines. The target product profile of these vaccines includes not only dose sparing but also high stability, which is important for stockpiling, and easy application important for (emergency) vaccination campaigns. In this review, the current status of alternative polio vaccine delivery strategies is given. Furthermore, we discuss the feasibility of these strategies by highlighting challenges, hurdles to overcome, and formulation issues relevant for optimal vaccine delivery.

KEYWORDS:

• Inactivated poliovirus vaccine
• vaccine delivery
• needle-free
• dermal
• mucosal

Financial and competing interests disclosure

This paper is funded indirectly by the Dutch government. The authors of this manuscript are staff of Intravacc, except for W van der Stel who is a student. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.