ISCOMATRIX™ adjuvant for prophylactic and therapeutic vaccines

Abstract

The ISCOMATRIX™ adjuvant has antigen-delivery and -presentation properties, as well as immunomodulatory capabilities that combine to provide enhanced and accelerated immune responses. The responses are broad, including a range of subclasses of antibodies as well as both CD4⁺ and CD8⁺ T cells. A range of ISCOMATRIX vaccines (ISCOMATRIX adjuvant combined with antigen) have been evaluated in clinical trials. The results of these completed and ongoing studies indicate that the ISCOMATRIX adjuvant is safe and generally well tolerated and increases the vaccine immune responses.

Keywords::

• adjuvant
• antibody
• immunotherapy
• ISCOMATRIX
• T cell
• vaccine

Acknowledgements

The authors acknowledge Gina Kanesoulis for her valuable assistance in preparing the manuscript. The authors are also grateful for the valuable contribution of their colleagues at CSL, in particular Nick Wilson, Denise Airey and Nina Kennet, as well as academic and industry partners for their interest and scientific endeavors directed towards better defining our understanding of ISCOMATRIX adjuvant, the manufacturing process, and progressing the clinical development of ISCOMATRIX vaccines. We would also like to acknowledge Ross Hamilton and Alex Hyatt for the cryoelectron micrograph. Thanks also go to John Cox for critical review of the manuscript. ISCOMATRIX and ISCOPREP are trademarks of ISCOTEC AB, a CSL company.

Financial & competing interests disclosure

All authors are employees of CSL. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Writing assistance was utilized in the production of this manuscript. This was funded by CSL as part of DD budget.