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Expert Review of Cardiovascular Therapy Volume 5, 2007 - Issue 1
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Review

Cell transplantation for treatment of left-ventricular dysfunction due to ischemic heart failure: from bench to bedside

Aravinda Nanjundappa East Carolina University, Director of Vascular Medicine and Peripheral Vascular Interventions Assistant Professor of Medicine, Department of Internal Medicine, Division of Cardiology, 600 Moye Blvd, TA 378, Greenville, NC 27834, USA. [email protected]
,
Jaffar Ali Raza Cardiology fellow, Department of Internal Medicine, Division of Cardiology, East Carolina University, 600 Moye Blvd, TA 378, Greenville, NC 27834, USA
,
Robert S Dieter Assistant Professor of Medicine, Loyola University, Department of Cardiology, Chicago, IL, USA
,
Sangeeta Mandapaka Cardiology fellow, Department of Internal Medicine, Division of Cardiology, East Carolina University, 600 Moye Blvd, TA 378, Greenville, NC 27834, USA
&
Wayne E Cascio Chief of Division of Cardiology, Department of Internal Medicine, Professor of Medicine, East Carolina University, 600, Moye Blvd, TA 378, Greenville, NC 27834, USA
Pages 125-131 | Published online: 10 Jan 2014
 
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Abstract

Cell transplantation is an innovative technology that involves the implantation of a variety of myogenic and angiogenic cell types. The transplanted cells proliferate and augment left ventricular performance and therein ameliorate the heart failure symptoms. The concept of cell transplantation has followed the footsteps of angiogenesis starting as bench side research. The latter half of the decade saw the transformation of this potential mechanism to a promising therapy for ischemic heart failure. More than 150 patients have been treated with cellular transplantation worldwide. This novel application has the potential to revolultionalize alternative therapeutic approaches to management of heart failure.

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