Proteomic diagnosis of Sjögren’s syndrome

Abstract

In the last few years, a growing interest has arisen in the application of proteomic analysis to rheumatic disease. Sjögren’s syndrome is a systemic disease that affects exocrine glands directly, and is therefore expected to influence the composition of the whole human saliva and lachrymal fluid. Therefore, a rising number of studies have been performed in an attempt to characterize the salivary and lachrymal protein profiles of patients with Sjögren’s syndrome by using a proteomic approach. This review summarizes the state of the art and the potential application of proteomics in the systematic search for diagnostic biomarkers in Sjögren’s syndrome.

Keywords::

• 2DE
• mass spectrometry
• proteomics
• rheumatic disease
• saliva
• salivary glands
• Sjögren’s syndrome
• tear

Acknowledgments

The authors wish to thank Wendy Doherty for her valuable contribution in reviewing the text.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.