Esophageal tissue engineering

Abstract

Esophageal tissue engineering is still in an early state, and ideal methods have not been developed. Since the beginning of the 20th century, advances have been made in the materials that can be used to produce an esophageal substitute. Three approaches to scaffold-based tissue engineering have yielded good results. The first development concerned non-absorbable constructs based on silicone and collagen. The need to remove the silicone tube is the main disadvantage of this material. Polymeric absorbable scaffolds have been used since the 1990s. The main polymeric material used is poly (glycolic) acid combined with collagen. The problem of stenosis remains prevalent in most studies using an absorbable construct. Finally, decellularized scaffolds have been used since 2000. The promises of this new approach are unfulfilled. Indeed, stenosis occurs when the esophageal defect is circumferential regardless of the scaffold materials. Cell supplementation can decrease the rate of stenosis, but the type(s) of cells and their roles have not been defined. Finally, esophageal tissue engineering cannot provide a functional esophageal substitute, and further development is necessary prior to conducting human clinical studies.

Keywords::

• cells seeding
• esophagus
• scaffolds
• stenosis
• tissue engineering

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

No writing assistance was utilized in the production of this manuscript.

Key issues

• Esophageal tissue engineering has been utilized for more than a century.

• Recent developments in scaffold preparation are promising.

• Decellularized scaffolds may be superior to manufactured scaffolds. However, they do not decrease long-term morbidity.

• The main complication is stenosis of the esophageal substitute, which occurs when the replacement is circumferential.

• Supplementation with cells may decrease the stenosis phenomenon. However, the type(s) of cells required has not been clearly defined.

• Esophageal substitution in animal models is not similar to that of humans.