The Nobori biolimus-eluting stent: update of available evidence

Abstract

Despite first-generation drug-eluting stents (DES) dramatically reduced the need for repeat revascularization in patients undergoing percutaneous coronary intervention, their use was associated with an increased risk of thrombotic events at long-term follow-up. The Nobori biolimus-eluting stent (BES) is a second-generation DES with a biodegradable poly-lactic acid polymer. During the last few years, several randomized trials have compared the Nobori BES with other DES, making this device the most investigated biodegradable DES. In this article, we reviewed current available data about Nobori BES from pharmacokinetic and observational studies to randomized clinical trials.

Keywords::

• biodegradable stent
• biolimus-eluting stent
• drug-eluting stent
• Nobori stent
• percutaneous coronary intervention

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Key issues

• The Nobori biolimus-eluting stent (BES; Terumo, Tokyo, Japan) is a second-generation drug-eluting stent with a biodegradable polylactic acid polymer.

• In patients undergoing percutaneous coronary intervention, the use of biodegradable polymer is expected to improve clinical outcomes by reducing the risk of late adverse events such as stent thrombosis.

• Current data from randomized comparisons of Nobori BES with permanent polymer drug-eluting stents demonstrated the noninferiority of Nobori BES with an equivalent 1 year safety and efficacy in more than 12,000 patients.

• However, updated data with long-term follow-up are needed to evaluate the potential Nobori BES superiority after polymer degradation.

Notes