Targeting vesicular monoamine transporter Type 2 for noninvasive PET-based β-cell mass measurements

Abstract

The common pathology in both Types 1 and 2 diabetes is insufficient β-cell mass to meet the metabolic needs of insulin production. The rising worldwide incidence of diabetes, combined with the lack of reliable endpoints of the body’s true capacity to produce insulin, constitute a serious dilemma facing healthcare professionals and the pharmaceutical industry. Recent advances in imaging science and molecular imaging chemistry, as well as a broader understanding of basic islet biology, now allow the collection of quantitative information about β cells deep within the pancreas. The ability to noninvasively measure the mass of insulin-producing cells will most likely be of value towards characterizing new drugs and refining the diagnosis and treatment of this burdensome disease.

Keywords::

• β cell
• diabetes
• imaging
• pancreas
• PET

Acknowledgements

This work was supported by a grant from the PHS, NIH, NIDDK 2 RO1 DK63567–04 and NIDDK 1 RO1 DK077493–01. The authors thank Stanislao Leone and Kristi Hultman for their contributions to this work. The authors have no financial or other arrangements that represent a conflict of interest.