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Expert Review of Clinical Immunology Volume 1, 2005 - Issue 2
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Review

Natural autoantibodies: immune homeostasis and therapeutic intervention

Jagadeesh Bayry Institut des Cordeliers, INSERM U681, 15 Rue de l’Ecole de Médecine, 75006 Paris, France. [email protected]; The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, UK . [email protected]
,
Namita Misra Institut des Cordeliers, INSERM U681, 15 Rue de l’Ecole de Médecine, 75006 Paris, France. [email protected]
,
Suryasarathi Dasgupta Institut des Cordeliers, INSERM U681, 15 Rue de l’Ecole de Médecine, 75006 Paris, France. [email protected]
,
Sébastien Lacroix-Desmazes Institut des Cordeliers, INSERM U681, 15 Rue de l’Ecole de Médecine, 75006 Paris, France. [email protected]
,
Michel D Kazatchkine Institut des Cordeliers, INSERM U681, 15 Rue de l’Ecole de Médecine, 75006 Paris, France. [email protected]
&
Srini V Kaveri Institut des Cordeliers, INSERM U681, 15 Rue de l’Ecole de Médecine, 75006 Paris, France. [email protected]
Pages 213-222 | Published online: 10 Jan 2014
 
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Abstract

The importance of natural autoantibodies reacting with self-antigens has long been neglected, as tolerance to self was believed to be primarily dependent on the deletion of autoreactive clones during ontogeny. However, it is now well established that autoreactive antibodies and B- and T-cells are present in healthy individuals. Research into the properties of natural autoantibodies and their role in immune homeostasis has been extensively investigated for a number of years. This information should lead towards the therapeutic exploitation of natural autoantibodies in the immunotherapy of autoimmune and inflammatory disorders.

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