CD4⁺CD25⁺ regulatory T-cell therapy

Abstract

Naturally occurring CD4⁺CD25⁺ regulatory T cells (Tregs) expressing forkhead transcript factor box P3 have been established as a key regulator for the control of autoimmunity. A growing body of experiments in animal models has provided compelling evidence that the adoptive transfer of CD4⁺CD25⁺ Tregs can cure many autoimmune and allergic diseases, and appear to induce donor-specific transplantation tolerance. Thus, customer-tailored CD4⁺CD25⁺ Tregs have emerged as potential reagents for adoptive cell therapy for individualized medicine. This review discusses recent advances towards that goal.

Keywords::

• adoptive cell therapy
• allergy and autoimmune disease
• CD4+CD25+ T cells
• FoxP3
• regulatory T cells
• transplantation tolerance