Human mannose receptor (CD206) in immune response: novel insights into vaccination strategies using a humanized mouse model

Abstract

Evaluation of: He LZ, Crocker A, Lee J et al. Antigenic targeting of the human mannose receptor induces tumor immunity. J. Immunol. 178(10), 6259–6267 (2007).

Induction of adaptive immune response requires, in most cases, internalization of the antigen by professional antigen-presenting cells. Various endocytic receptors may mediate such interaction. However, little is known regarding the exact participation of such receptors in the context of immune response in vivo. This paper evaluates a recent work that utilizes one such molecule, the human CD206, transgenically incorporated into mouse, in order to establish its role in immune response. Such a study benefits from the fact that the function of the human form of the receptor is elaborated and thus would help to define new targets for future vaccine strategies.

Keywords::

• adjuvancy
• antibody-mediated targeting
• antigen-presenting cell
• endocytic receptor
• immune response
• mannose receptor
• therapeutic tumor regression

Financial disclosure

The authors have no relevant financial interests related to this manuscript, including employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.